If you’ve started a new antidepressant and suddenly feel wiped out, you’re not alone. Fatigue is one of the most common complaints when people begin or adjust their medication. It can feel like your body’s on a low‑power mode, even if you’re getting enough sleep. The good news? You can often manage this side effect without ditching the drug that’s helping your mood.
Most antidepressants work by changing the balance of neurotransmitters in the brain. SSRIs (like fluoxetine or sertraline), SNRIs (such as venlafaxine), and older tricyclics can all slow down certain pathways that keep you alert. The result is a dip in stamina, especially during the first few weeks. Your body is simply adapting to the new chemistry.
Another factor is timing. Some pills are designed to be taken in the morning, while others are better at night. Taking a “morning” medication too late can push the sleepy effect right into your daytime schedule.
1. Adjust the dose timing. If your doctor prescribed a morning dose but you feel drowsy at lunch, try moving it to early morning or with breakfast. Small shifts can make a big difference.
2. Move slowly with dosage. Some people jump to the full dose right away. Tapering up over a week or two gives your system a chance to adjust, often reducing fatigue.
3. Stay active. Light exercise – a 20‑minute walk, yoga, or gentle stretching – boosts circulation and releases endorphins. It may sound counter‑intuitive when you’re tired, but activity usually wins over fatigue.
4. Watch your caffeine and sugar. A cup of coffee can help, but too much can crash later. Same with sugary snacks – they give a quick spike then a slump.
5. Prioritize sleep hygiene. Keep the bedroom dark, cool, and screen‑free. Even a short nap (20‑30 minutes) can reset your energy without interfering with nighttime rest.
6. Talk to your prescriber. If fatigue persists after a couple of weeks, your doctor might switch you to a different antidepressant or add a low‑dose stimulant that’s safe with mood meds.
Remember, every brain reacts a bit differently. What works for one person might not work for another, so a little trial and error is normal.
Bottom line: antidepressant fatigue is manageable. By tweaking when you take your pill, moving a bit more, and keeping an eye on diet and sleep, you can stay on the medication that supports your mental health while reclaiming your daily energy.
Feel free to explore the other articles tagged with “antidepressant fatigue” on our site for deeper dives into specific drugs, real‑world experiences, and expert advice.
Explore how Vortioxetine, a multimodal antidepressant, can alleviate fatigue in major depression, backed by trial data, mechanisms and practical tips.